Cooper's method using 24 hour serum lithium level and Norman's method using renal lithium clearance after a single loading dose were compared to determine which predicted therapeutic lithium dose better. The author concluded the Norman's method
was
superior after evaluating the accuracy. The rapidity, and the utility of the two methods. And the author suggest the availabilty of the predicting methods to overcome the limitations of lithium therapy, such as the narrow range of therapeutic
level. The
time-consumption reaching therapeutic level, the time-consumption reaching therapeutic level, and the individual variation of therapeutic dose.
@ES The summary of results were as follows:
@EN 1) In Cooper's method, the objects included in the acute therapeutic level, 0.80~1.20mEq/l, were only 10 of 19 objects after taking prdeicted lithium dose.
2) In Norman's method, the objects included in the acute therapeutic level ere all of 19 objects, and the actual serum lithium level, 0.80~1.15mEq/l,were predicted with average error±4.89%.
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